Accelerating the development of targeted neuromodulation therapies

The first phase called on scientists, engineers, and clinicians to submit novel concepts and plans for development.

Neuromod Prize

Congratulations to the Phase 1 winners

Anthony F. DiMarco, M.D.

High-frequency spinal cord stimulation reduces respiratory tract infections and improves bowel management in people with neurological impairment

BIOS Health

The Autonomic Therapy Initiative, data-driven stimulations of the vagus nerve using neural biomarkers, modulates cardiac function and minimizes side effects on off target organs

GE Research in collaboration with Northwell Health and Yale University

A single, image-guided ultrasound treatment induces a response in the gut-brain sensory pathway to provide sustained remission in Type 2 diabetes and obesity

NPR Lab at the University of Connecticut

Synchronized pulse and sinusoidal stimulation of sacral dorsal root ganglia (DRG) and nerve roots relieves chronic visceral pain in the lower abdominal organs by selectively blocking C-fiber neural transmission

RBI Medical

Ultraprecise, selective pelvic neuromodulation therapy treats stress urinary incontinence, overactive bladder, and fecal incontinence using a minimally invasive micro-implant

University of Louisville Research Foundation Inc.

StimXS, neuromodulation of the lumbosacral spinal cord, automatically regulates cardiovascular, respiratory, and urinary systems after spinal cord injury

University of Pittsburgh Department of Urology

A multichannel implantable device for sacral-pudendal neuromodulation addresses bladder, bowel, and sexual disorders

Warren Grill & collaborators, Duke Biomedical Engineering

Electrical recording and stimulation of the sacral nerve with closed-loop bioelectronic control restores bladder and bowel function

About the competition

The Neuromod Prize is a SPARC (Stimulating Peripheral Activity to Relieve Conditions) initiative from the National Institutes of Health (NIH) Common Fund. The competition seeks groundbreaking uses of peripheral nerve stimulation that can independently regulate two or more desired autonomic functions without unintended effects on non-target organs. At the discretion of NIH, additional competition phases may follow Phase 1.


Phase 1

Open to all eligible participants

Participants submitted concept papers describing their proposed therapeutic approach and plans for conducting proof-of-concept studies. They competed for a share of the total prize pool.


Phase 2

Open to winners of Phase 1

Eight Phase 1 winners have been exclusively invited to develop proof-of-concept studies and compete for a share of the total prize pool.



Phase 3

Open to winners of Phase 2

Up to four Phase 2 winners may subsequently be selected to conduct IDE-enabling studies and compete for a share of the total prize pool.


Phase 1 prize

judging panel selected eight winners according to official Phase 1 judging criteria. Phase 1 winners will receive a share of the Phase 1 prize pool (up to $800,000) and the opportunity to participate in a planned Phase 2.


With $9.8 million total prize pool planned across three phases

Phase 1 timeline

Submission period

January 18 - April 28, 2022

Virtual information session

February 7, 2022

Technical considerations panel

March 9, 2022

Submission deadline

April 28, 2022


May - June 2022
We are here

Phase 1 winner announcement

July 2022

Phase 2 launch

Late summer 2022
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